Product Name :
PICK1 Recombinant Rabbit Monoclonal Antibody [JG30-80]
Predicted band size :
Observed band size :
Synonyms:
dJ1039K5 antibody MGC15204 antibody OTTHUMP00000028509 antibody PICK 1 antibody Pick1 antibody PICK1_HUMAN antibody PRKCA binding protein antibody PRKCA-binding protein antibody PRKCABP antibody Protein interacting with C kinase 1 antibody 展开
Function :
Protein interacting with C kinase 1 (PICK1) is a PDZ-domain containing protein that is located in the perinuclear region and is phosphorylated in response to PKCα activation. PKCα, which is essential for the regulation of proliferation and differentiation in numerous cell types, contains within its catalytic region a PDZ-binding domain that is absent from other PKC isoforms. Mutation of the PICK1 PDZ domain inhibits the binding of PICK1 to PKCα. PICK1 also interacts with the carboxy terminus of a-amino-3-hydroxy-5-methyl-isoxazole-4-propionic acid (AMPA) receptor, a neurotransmitter receptor located at excitatory synapses, suggesting that PICK1 plays a role in the modulation of synaptic transmission by targeting and anchoring AMPA to specific synapses.
Antibody Type:
Recombinant Rabbit monoclonal Antibody
Immunogen :
Synthetic peptide within Human PICK1 aa 1-50 / 415.1363381-55-8 structure
Species reactivity:
Human, Mouse, Rat
Verify application:
WB, IP, FC
Coupling :
unconjugated
Clone number:
JG30-80
RRID:
AB_3070857
Form :
Liquid
Concentration :
1ug/ul
Storage instructions:
Store at +4℃ after thawing.Price of 878155-85-2 Aliquot store at -20℃.PMID:33645258 Avoid repeated freeze / thaw cycles.
Storage buffer solution:
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Subtype:
IgG
Purification method :
Protein A affinity purified.
ELTSA :
Molecular weight :
47 kDa
Positive control :
SK-Br-3 cell lysate, 293 cell lysate, 293T.