Product Name :
3-Amino-1,2,4-triazole (CAS 61-82-5)
Synonym :
Aminotriazole; Amitrole
Application :
3-Amino-1,2,4-triazole is an irreversible catalase inhibitor
CAS:
61-82-5
Purity:
≥95%
Molecular Weight:
84.08
Formula :
C2H4N4
Physical state:
Solid
solubility :
Soluble in water (280 g/l at 20° C), methanol, ethanol, chloroform, and ethyl acetate (slightly). Insoluble in ether, and acetone.
Shipping Condition :
Store at 4° C
Melting point:
150-153° C (lit.)
SMILES:
C1=NNC(=N1)N
References:
:A bacterial two-hybrid selection system for studying protein-DNA and protein-protein interactions.166881-42-1 Description | Joung, JK., et al. 2000. Proc Natl Acad Sci U S A. 97: 7382-7. PMID: 108529473-amino-1,2,4-triazole inhibits macrophage NO synthase. | Buchmüller-Rouiller, Y., et al. 1992. Biochem Biophys Res Commun. 183: 150-5. PMID: 1371917Dose- and time-dependent effect of an acute 3-amino-1,2,4-triazole injection on rat brain catalase activity. | Aragon, CM., et al. 1991. Biochem Pharmacol. 42: 699-702. PMID: 1859472Efficient methodology for the synthesis of 3-amino-1,2,4-triazoles. | Noël, R., et al. 2009. J Org Chem. 74: 7595-7. PMID: 19731897Impact of 3-Amino-1,2,4-Triazole (3-AT)-Derived Increase in Hydrogen Peroxide Levels on Inflammation and Metabolism in Human Differentiated Adipocytes. | Ruiz-Ojeda, FJ., et al. 2016. PLoS One. 11: e0152550. PMID: 270237993-Amino-1,2,4-triazole Limits the Oxidative Damage in UVA-Irradiated Dysplastic Keratinocytes. | Nechifor, MT. and Dinu, D. 2017. Biomed Res Int. 2017: 4872164. PMID: 29387721Strategies for synthesis of 1,2,4-triazole-containing scaffolds using 3-amino-1,2,4-triazole. | Nasri, S., et al. 2022. Mol Divers. 26: 717-739. PMID: 33608844Structure and IR spectroscopic properties of complexes of 1,2,4-triazole and 3-amino-1,2,4-triazole with dinitrogen isolated in solid argon. | Mucha, K., et al. 2023. Spectrochim Acta A Mol Biomol Spectrosc.218595-22-3 supplier 285: 121901.PMID:33593842 PMID: 36182831The reaction of 3-diazonium-1,2,4-triazole with tryptophan at acid pH: a scintillation method for tryptophan determination in proteins. | DeTraglia, MC., et al. 1979. Anal Biochem. 99: 464-73. PMID: 574724Specific regulatory interconnection between the leucine and histidine pathways of Neurospora crassa. | Kidd, GL. and Gross, SR. 1984. J Bacteriol. 158: 121-7. PMID: 6325383Mechanisms of increasing expression of a yeast gene in Escherichia coli. | Brennan, MB. and Struhl, K. 1980. J Mol Biol. 136: 333-8. PMID: 6990004Catalase inhibition with 3-amino-1,2,4-triazole does not abolish infarct size reduction in heat-shocked rats. | Auyeung, Y., et al. 1995. Circulation. 92: 3318-22. PMID: 7586320Effect of 3-aminotriazole on hyperthermia-mediated cardioprotection in rabbits. | Kingma, JG., et al. 1996. Am J Physiol. 270: H1165-71. PMID: 8967353