Product Name :
21-Hydroxyprogesterone (CAS 64-85-7)
Synonym :
Desoxycorticosterone
Application :
21-Hydroxyprogesterone is a mineralocorticoid
CAS:
64-85-7
Purity:
Molecular Weight:
330.46
Formula :
C21H30O3
Physical state:
Solid
solubility :
Shipping Condition :
Store at room temperature
Melting point:
139° C
SMILES:
C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO
References:
:Cytochrome P450 3A9 catalyzes the metabolism of progesterone and other steroid hormones. | Wang, H., et al. 2000. Mol Cell Biochem. 213: 127-35. PMID: 11129951Determination of 3-keto-4-ene steroids and their hydroxylated metabolites catalyzed by recombinant human cytochrome P450 1B1 enzyme using gas chromatography-mass spectrometry with trimethylsilyl derivatization. | Song, J., et al. 2003. J Chromatogr B Analyt Technol Biomed Life Sci. 791: 127-35. PMID: 12798173Bifunctional gonadotropin-releasing hormone antagonist-progesterone analogs with increased efficacy and duration of action. | Ratcliffe, KE., et al. 2006. Endocrinology. 147: 571-9. PMID: 16223868The glucuronidation of Delta4-3-Keto C19- and C21-hydroxysteroids by human liver microsomal and recombinant UDP-glucuronosyltransferases (UGTs): 6alpha- and 21-hydroxyprogesterone are selective substrates for UGT2B7. | Bowalgaha, K., et al. 2007. Drug Metab Dispos. 35: 363-70. PMID: 17151189Real-time analysis of gene regulation by glucocorticoid hormones. | McMaster, A., et al. 2008. J Endocrinol. 197: 205-11. PMID: 18434350A hypervariable region of P450IIC5 confers progesterone 21-hydroxylase activity to P450IIC1. | Kronbach, T., et al. 1991. Biochemistry. 30: 6097-102. PMID: 2059619A sensitive and rapid mass spectrometric method for the simultaneous measurement of eight steroid hormones and CALIPER pediatric reference intervals. | Kyriakopoulou, L., et al. 2013. Clin Biochem. 46: 642-51. PMID: 23337690Progesterone hydroxylation by cytochromes P450 2C and 3A enzymes in marmoset liver microsomes. | Nakanishi, K., et al. 2018. Xenobiotica. 48: 757-763. PMID: 28762864Biotransformation of Progesterone by the Ascomycete Aspergillus niger N402. | Savinova, OS., et al. 2018. Biochemistry (Mosc). 83: 26-31. PMID: 29534665Simultaneous solubilization of steroid hormones I: estrogens and C21 steroids.BuySM-102 | Lövgren, T.Buy3-Iodo-4-(trifluoromethyl)aniline , et al.PMID:33392917 1978. J Pharm Sci. 67: 1419-22. PMID: 702293Identification of progesterone binding sites in the plasma membrane of the filamentous fungus Cochliobolus lunatus. | Plemenitas, A., et al. 1993. J Steroid Biochem Mol Biol. 45: 281-5. PMID: 8499335The carboalkoxyallylsilane terminator for biomimetic polyene cyclizations. A route to 21-hydroxyprogesterone types | William S. Johnson, Clive Newton, Stephen D. Lindell. 1986. Tetrahedron Letters. 27: 6027-6030.Biotransformation of progesterone by the green alga Chlorella emersonii C211-8h | Marina Della Greca ‡, Antonio Fiorentino ‡, Gabriele Pinto , Antonino Pollio , Lucio Previtera ‡. 1996. Phytochemistry. 41: 1527-1529.Studies on Geobacillus stearothermophilus-Part V1: Transformation of 17 alpha -hydroxyprogesterone and 21-hydroxyprogesterone | Sameera Al-Awadi, Mohammed Afzal & Sosamma Oommen. 2006. Biocatalysis and Biotransformation. 25: 43-50.