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Johansson et al. Nutrition Journal 2013, 12:46 http://nutritionj/content/12/1/RESEARCHOpen AccessEffects of indigestible carbohydrates in barley on glucose metabolism, appetite and voluntary food intake over 16 h in healthful adultsElin V Johansson*, Anne C Nilsson, Elin M tman and Inger M E Bj ckAbstractBackground: Recent information in animals suggests that gut microbial metabolism could influence host metabolism, which includes appetite regulating hormones. The aim with the present study was to evaluate the prospective effects of a entire grain barley kernel solution, wealthy in intrinsic indigestible carbohydrates (dietary fibre and resistant starch), on markers of metabolism and appetite regulation in healthy subjects.N-Cyano-2-pyridinecarboximidamide supplier Solutions: Boiled barley kernels (BK) or white wheat bread (WWB; reference) were provided as late evening meals to 19 young adults in random order working with a cross-over design.PMID:33627016 During subsequent ad libitum standardized breakfast and lunch meals (ten.5-16 h), blood was collected for evaluation of glucose, plasma insulin, adiponectin, ghrelin, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), serum free of charge fatty acids (FFA) and interleukin (IL)-6. Furthermore, appetite sensations, voluntary energy intake and breath H2 were determined. Benefits: BK as evening meal enhanced plasma GLP-1 at fasting (P 0.05) and for the duration of the experimental day (P 0.01) compared with WWB. Moreover the BK evening meal decreased fasting serum FFA (P 0.05) and tended to lower fasting serum IL-6 (P = 0.06). At lunch, preceded by BK evening meal, voluntary energy intake was decreased (P 0.05) when when compared with WWB evening meal. The BK evening meal decreased incremental blood glucose region (P 0.01), promoted larger breath H2 (P.